Buy Cialis - Cheapest Cialis - Levitra : Article : 2695

Warning: fopen(/home/ameindus/public_html/one-levitra.com/cache/lastclean.txt) [function.fopen]: failed to open stream: No such file or directory in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 41

Warning: fwrite(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 42

Warning: fclose(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 43

Warning: fopen(/home/ameindus/public_html/one-levitra.com/cache/8b7bdecd32c41a6f5001e81b8b673b37) [function.fopen]: failed to open stream: No such file or directory in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 128

Warning: fwrite(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 129

Warning: fclose(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 130

Levitra News

May 10, 2004 - 14:28

Genetic risk factors for erectile dysfunction and genetic determinants of drug response--on the way
Author: Sexual Health News

"Eisenhardt A, Siffert W. Institute of Pharmacology, University Hospital Essen, Germany. Andreas.Eisenhardt Association studies give hint for the fact that the risk to develop cardiovascular disorders such as hypertension or coronary heart disease is influenced by the genotype in single nucleotide polymorphisms (SNPs). Considering the close relationship in the pathophysiology of these diseases and erectile dysfunction (ED), the analysis of the association of genotypes in SNPs and ED stands to reason. In an analysis of ED patients and their genotypes in the GNB3 C825T, the ACE I/D and the NOS3 G894T polymorphisms, there was no evidence for influence of the genotypes on the susceptibility to develop ED. At the same time, a significant variation in drug response to sildenafil dependent on the genotypes in the GNB3 C825T and ACE I/D polymorphisms was demonstrated. In the group of GNB3 825C allele carriers, only 50% of patients showed a positive response, while > 90% of the patients genotype TT responded adequately. In parallel, only 50% of ACE D allele carriers showed a positive response to sildenafil in contrast to men genotype II in the ACE I/D polymorphism, who had a response rate of 75%. Considering cardiovascular side effects under sildenafil treatment, it would be interesting to determine if genetic factors have an impact on the side effect profile of this drug. Publication Types:  Review  Review, Academic MeSH Terms:  Angiotensin I/genetics  Animals  Genotype*  Human  Impotence/diagnosis  Impotence/drug therapy  Impotence/genetics*  Male  Nitric-Oxide Synthase/genetics  Phosphodiesterase Inhibitors/adverse effects  Phosphodiesterase Inhibitors/therapeutic use*  Piperazines/therapeutic use*  Polymorphism, Single Nucleotide/genetics*  Treatment Outcome  Vasodilator Agents/adverse effects  Vasodilator Agents/therapeutic use* Substances:  Phosphodiesterase Inhibitors  Piperazines  Vasodilator Agents  sildenafil  Angiotensin I  endothelial constitutive nitric oxide synthase  Nitric-Oxide Synthase PMID: 12825146 [PubMed] "

Back to News

Buy Levitra - Cheapest Levitra - Viagra
Warning: fopen(/home/ameindus/public_html/one-levitra.com/cache/lastclean.txt) [function.fopen]: failed to open stream: No such file or directory in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 41

Warning: fwrite(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 42

Warning: fclose(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 43

Warning: fopen(/home/ameindus/public_html/one-levitra.com/cache/0528bc7d58454cfe643760b68cc89937) [function.fopen]: failed to open stream: No such file or directory in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 128

Warning: fwrite(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 129

Warning: fclose(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 130

Warning: fopen(/home/ameindus/public_html/one-levitra.com/cache/lastclean.txt) [function.fopen]: failed to open stream: No such file or directory in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 41

Warning: fwrite(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 42

Warning: fclose(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 43

Warning: fopen(/home/ameindus/public_html/one-levitra.com/cache/7e2dae35c3d1c0d4edbd7b783bd35605) [function.fopen]: failed to open stream: No such file or directory in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 128

Warning: fwrite(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 129

Warning: fclose(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 130
Help

Warning: fopen(/home/ameindus/public_html/one-levitra.com/cache/lastclean.txt) [function.fopen]: failed to open stream: No such file or directory in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 41

Warning: fwrite(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 42

Warning: fclose(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 43

Warning: fopen(/home/ameindus/public_html/one-levitra.com/cache/294513b8f48be0a44c11ae89721300da) [function.fopen]: failed to open stream: No such file or directory in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 128

Warning: fwrite(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 129

Warning: fclose(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 130

Warning: fopen(/home/ameindus/public_html/one-levitra.com/cache/lastclean.txt) [function.fopen]: failed to open stream: No such file or directory in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 41

Warning: fwrite(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 42

Warning: fclose(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 43

Warning: fopen(/home/ameindus/public_html/one-levitra.com/cache/ac8a9d79f390c5b3ac2396602ba48d1f) [function.fopen]: failed to open stream: No such file or directory in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 128

Warning: fwrite(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 129

Warning: fclose(): supplied argument is not a valid stream resource in /home/ameindus/public_html/one-levitra.com/exchange/ex_func.php on line 130